Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Tocris Bioscience™ NFκB p50 Transcription Factor Assay
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The transcription factor NFkB is involved in the expression and regulation of a number of important cellular and physiological processes such as growth, development, apoptosis, immune and inflammatory response
Tocris Bioscience™ RA 2
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Potent negative modulator of KCa2.3 and KCa3.1 channels
| Target | Ca2+-Activated Potassium Channel Modulators |
|---|---|
| CAS | 1867107-62-7 |
| Purity | 0.98 |
| Chemical Name or Material | 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate) |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C22H16F2O6 |
Tocris Bioscience™ Aprepitant
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Potent long-acting hNK-1 antagonist
Tocris Bioscience™ H 151
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STING antagonist
| Target | STING Antagonists |
|---|---|
| CAS | 941987-60-6 |
| Purity | 98% |
| Chemical Name or Material | N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea |
| Recommended Storage | Store at 4°C |
| Synonym | ERIS, hMITA, MITA, mitochondrial mediator of IRF3 activation, MPYS, NET23, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, sting, transmembrane protein 173 |
| Molecular Formula | C17H17N3O |
| Formula Weight | 279.34 |
Tocris Bioscience™ SB 431542
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Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
| CAS | 301836-41-9 |
|---|---|
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C22H16N4O3 |
| Formula Weight | 384.39 |
Tocris Bioscience™ endo-IWR 1
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endo-IWR 1 synthesized to Ancillary Material Grade
Tocris Bioscience™ VH 032, thiol
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Functionalized VHL ligand for PROTAC™; development
Tocris Bioscience™ sCy5DA
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FDAA for super-resolution microscopy of bacteria
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Tocris Bioscience™ CU-76
Tocris Bioscience™ CU-76
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Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
Tocris Bioscience™ CHDI 00580985
Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant
Tocris Bioscience™ Mag-Fura-2 AM
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Magnesium (Mg2+) indicator, membrane permeable
Tocris Bioscience™ Phen Green SK diacetate
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Heavy metal ion indicator, membrane permeable